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Do you know what the slogan "it's in your DNA" is really all about? Our ever improving ability to read anyone's genome sequence raises many issues regarding the social context of genomics. Information about our genomes is starting to become part of our everyday life. Genomic information shapes societal messages about DNA in how we think about ourselves and how others view us. Companies, universities, nonprofits, and many other organizations have used the slogan "it's in our DNA" to mean that something is part of their core mission or values.

15 for 15: Social Context

Is it the chin that looks like your mother's or the eye color that is just like your grandfather's? What story does your DNA tell about the hundreds or thousands of ancestors before you?

What continents did they migrate through in times long past? How does your DNA contribute to who you are, or how you are treated within your society? Continued studies of the ethical, legal, and social implications of genomic advances can help to break down barriers and yield a better appreciation of what truly is, and is not, in our DNA - and what that means to us, our families, and communities and society.

The scientists who launched the Human Genome Project recognized immediately that having a complete human genome sequence would raise many ethical and social issues.

The research supported by this program, ranges from genomics and health disparities to inclusion of diverse populations in genomics research, to whether people should have the right to refuse to know genomic testing results. Over the last 15 years, this research has greatly advanced our understanding and appreciation of the complex societal implications of genomics. For example, what do you need to know about a research study that will use your DNA before you agree to participate? That's called " informed consent. An IRB must approve any research projects involving humans.

The widespread availability of genomic data has brought changes to privacy considerations as well. Since you share half of your genome with each of your parents, and half with each of your children, the information is not just about your genome. Should you be able to stop your relatives from revealing genomic information that could be relevant to you as well? And does that answer change based on what the test is for? Another privacy issue that has arisen in the genomics era is when are you entitled to receive all of your data back from a DNA-based research study or a clinical test.

Google Scholar. Manuel Ruiz-Aravena.

Rodrigo Hamede. Menna E Jones.

Part 1: Forging a Genetic Paradigm for C

Matthew F Lawrance. Sarah A Hendricks. Austin Patton. Brian W Davis. Elaine A Ostrander. Hamish McCallum. Paul A Hohenlohe. Andrew Storfer. Corresponding author: E-mail: astorfer wsu. Cite Citation. Permissions Icon Permissions. Abstract Understanding the genetic basis of disease-related phenotypes, such as cancer susceptibility, is crucial for the advancement of personalized medicine. Open in new tab Download slide. Table 1. Table 2. Table 3. Genome-wide analysis of HPV integration in human cancers reveals recurrent, focal genomic instability.

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Search ADS. Conservation evo-devo: preserving biodiversity by understanding its origins. Projecting the performance of risk prediction based on polygenic analyses of genome-wide association studies. Manta: rapid detection of structural variants and indels for germline and cancer sequencing applications. Detection of bladder cancer using novel DNA methylation biomarkers in urine sediments. Complete spontaneous regression of Merkel cell carcinoma: a review of the 10 reported cases.

Mutational and selective effects on copy-number variants in the human genome. Genomic restructuring in the Tasmanian devil facial tumour: chromosome painting and gene mapping provide clues to evolution of a transmissible tumour. A framework for variation discovery and genotyping using next-generation DNA sequencing data. Molecular shifts in limb identity underlie development of feathered feet in two domestic avian species.

Active conservation of noncoding sequences revealed by 3-way species comparisons. Rapid evolutionary response to a transmissible cancer in Tasmanian devils. Exploring the occurrence of classic selective sweeps in humans using whole-genome sequencing data sets. Molecular signatures of regression of the canine transmissible venereal tumor. Prostate cancer: race and prostate cancer personalized medicine: the future. A unique cellular and molecular microenvironment is present in tertiary lymphoid organs of patients with spontaneous prostate cancer regression.

Biting injuries and transmission of Tasmanian devil facial tumour disease. Transmissible cancer in Tasmanian devils: localized lineage replacement and host population response. Defects in a cell cycle checkpoint may be responsible for the genomic instability of cancer cells. Emerging disease and population decline of an island endemic, the Tasmanian devil Sarcophilus harrisii.

Conservation implications of limited genetic diversity and population structure in Tasmanian devils Sarcophilus harrisii. Whole-genome sequence analyses of Western Central African Pygmy hunter-gatherers reveal a complex demographic history and identify candidate genes under positive selection. Whole-genome resequencing of extreme phenotypes in collared flycatchers highlights the difficulty of detecting quantitative trait loci in natural populations.

Individual genomes and personalized medicine: life diversity and complexity. Initial molecular-level response to artificial selection for increased aerobic metabolism occurs primarily through changes in gene expression.

The Genetics of Cancer

Genome-wide association study for colorectal cancer identifies risk polymorphisms in German familial cases and implicates MAPK signalling pathways in disease susceptibility. Density trends and demographic signals uncover the long-term impact of transmissible cancer in Tasmanian devils. The relative power of genome scans to detect local adaptation depends on sampling design and statistical method. FLASH: fast length adjustment of short reads to improve genome assemblies. Distribution and characterization of regulatory elements in the human genome.

Large-effect loci affect survival in Tasmanian devils infected with a transmissible cancer. Quantity, not quality: rapid adaptation in a polygenic trait proceeded exclusively through expression differentiation.

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Identification of altered cis -regulatory elements in human disease. Transmission dynamics of Tasmanian devils facial tumor disease may lead to disease-induced extinction. Widespread transmission of independent cancer lineages within multiple bivalve species.

Genetic diversity and population structure of the endangered marsupial Sarcophilus harrisii Tasmanian devil. Merkel cell carcinoma of the eyelid. Comparative transcriptomics reveals the conserved building blocks involved in parallel evolution of diverse phenotypic traits in ants. Genome sequencing and analysis of the Tasmanian devil and its transmissible cancer. The Tasmanian devil transcriptome reveals Schwann cell origins of a clonally transmissible cancer.

Spontaneous regression of Merkel cell carcinoma: a case report and review of the literature. Cancer regression and autoimmunity induced by cytotoxic T lymphocyte-associated antigen 4 blockade in patients with metastatic melanoma. The genetics of venom ontogeny in the eastern diamondback rattlesnake Crotalus adamanteus. An empirical test of the mutational landscape model of adaptation using a single-stranded DNA virus.

Journal of Genetics and Genome Research | Clinmed International Library

Adoptive cell transfer: a clinical path to effective cancer immunotherapy. Comparative oncology: what dogs and other species can teach us about humans with cancer. Reversible epigenetic down-regulation of MHC molecules by devil facial tumour disease illustrates immune escape by a contagious cancer.

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The topology of the possible: formal spaces underlying patterns of evolutionary change. The origins and vulnerabilities of two transmissible cancers in Tasmanian Devils.