Do you know what the slogan "it's in your DNA" is really all about? Our ever improving ability to read anyone's genome sequence raises many issues regarding the social context of genomics. Information about our genomes is starting to become part of our everyday life. Genomic information shapes societal messages about DNA in how we think about ourselves and how others view us. Companies, universities, nonprofits, and many other organizations have used the slogan "it's in our DNA" to mean that something is part of their core mission or values.
15 for 15: Social Context
Is it the chin that looks like your mother's or the eye color that is just like your grandfather's? What story does your DNA tell about the hundreds or thousands of ancestors before you?
What continents did they migrate through in times long past? How does your DNA contribute to who you are, or how you are treated within your society? Continued studies of the ethical, legal, and social implications of genomic advances can help to break down barriers and yield a better appreciation of what truly is, and is not, in our DNA - and what that means to us, our families, and communities and society.
The scientists who launched the Human Genome Project recognized immediately that having a complete human genome sequence would raise many ethical and social issues.
The research supported by this program, ranges from genomics and health disparities to inclusion of diverse populations in genomics research, to whether people should have the right to refuse to know genomic testing results. Over the last 15 years, this research has greatly advanced our understanding and appreciation of the complex societal implications of genomics. For example, what do you need to know about a research study that will use your DNA before you agree to participate? That's called " informed consent. An IRB must approve any research projects involving humans.
The widespread availability of genomic data has brought changes to privacy considerations as well. Since you share half of your genome with each of your parents, and half with each of your children, the information is not just about your genome. Should you be able to stop your relatives from revealing genomic information that could be relevant to you as well? And does that answer change based on what the test is for? Another privacy issue that has arisen in the genomics era is when are you entitled to receive all of your data back from a DNA-based research study or a clinical test.
Google Scholar. Manuel Ruiz-Aravena.
Rodrigo Hamede. Menna E Jones.
Part 1: Forging a Genetic Paradigm for C
Matthew F Lawrance. Sarah A Hendricks. Austin Patton. Brian W Davis. Elaine A Ostrander. Hamish McCallum. Paul A Hohenlohe. Andrew Storfer. Corresponding author: E-mail: astorfer wsu. Cite Citation. Permissions Icon Permissions. Abstract Understanding the genetic basis of disease-related phenotypes, such as cancer susceptibility, is crucial for the advancement of personalized medicine. Open in new tab Download slide. Table 1. Table 2. Table 3. Genome-wide analysis of HPV integration in human cancers reveals recurrent, focal genomic instability.
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The Genetics of Cancer
Genome-wide association study for colorectal cancer identifies risk polymorphisms in German familial cases and implicates MAPK signalling pathways in disease susceptibility. Density trends and demographic signals uncover the long-term impact of transmissible cancer in Tasmanian devils. The relative power of genome scans to detect local adaptation depends on sampling design and statistical method. FLASH: fast length adjustment of short reads to improve genome assemblies. Distribution and characterization of regulatory elements in the human genome.
Large-effect loci affect survival in Tasmanian devils infected with a transmissible cancer. Quantity, not quality: rapid adaptation in a polygenic trait proceeded exclusively through expression differentiation.
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